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TribioScience | SKU: TBI3306-5MG

Mocetinostat, Class I HDAC inhibitor (TBI3306)

Name: Mocetinostat, Class I HDAC inhibitor (TBI3306)
Brand: TribioScience
SKU: TBI3306-5MG
Price: 126.0 USD
Availability: InStock

$126.00

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TribioScience

Mocetinostat, Class I HDAC inhibitor (TBI3306)

From $126.00

Description

Product Details

Formal Name: N-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide

Alternate Names: MGCD0103

Molecular Formula: C₂₃H₂₀N₆O

Formula Weight: 396.44

CAS Number: 726169-73-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

Class I HDAC inhibitor

Functions

Class I, isoform-selective HDAC inhibitor, IC50s=0.15, 0.29, 1.66 and 0.59 μM for HDAC1, 2, 3 and 11 respectively. Induces hyperacetylation of histones, induces expression of the tumor suppressor p21WAF1 and inhibits proliferation of human cancer cells. Displays antifibrotic effects in ischemic heart failure. Attenuates the development of hypersensitivity in models of neuropathic pain. Active in vivo.