ML-297, GIRK activator (TBI1469)

Description

Product Details

Formal Name: N-(3.4-Difluorophenyl)-n’-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea

Alternate Names: VU0456810

Molecular Formula: C₁₇H₁₄F₂N₄O

Formula Weight: 328.32

CAS Number: 1443246-62-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 20 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

GIRK activator

Functions

Selective GIRK ½ (Kir3.1/3.2) channel activator, IC50 = 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively. Has no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels. Displays antiseizure activity and decreases anxiety-related behavior without sedative or addictive effects. Reduces glucose- and IBMX-stimulated GLP-1 secretion with no effect on GIP in murine L and K cells. Brain penetrant.

Application Procedures

First dissolved in DMSO (up to 45 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.