Mito-TEMPO, Mitochondria targeted antioxidant (TBI4100)

Description

Product Details

Formal Name: (2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride

Molecular Formula: C₂₉H₃₅ClN₂O₂P

Formula Weight: 510.00

CAS Number: 1334850-99-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml), in Water (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Mitochondria targeted antioxidant

Functions

Mitochondria-targeted antioxidant. Partially prevents mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery. Resolves mitochondrial oxidative stress and rescues coronary collateral growth in Zucker obese fatty rats. Protects mitochondrial membrane potential and attenuates reperfusion-induced ROS production in a mouse ventricular myocyte model. Abrogates the induction of senescence in a human vascular smooth muscle cell model.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), in Water (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml), then diluted to aqueous buffer.