Mito-lonidamine, Mitochondria-targeted antiglycolytic agent (TBI5492)

Description

Product Details

Formal Name: (10-(1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxamido)decyl)triphenylphosphonium bromide

Molecular Formula: C₄₃H₄₅BrCl₂N₃OP

Formula Weight: 801.60

CAS Number: 2361564-49-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (30 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Mitochondria-targeted antiglycolytic agent

Functions

Lonidamine is an antiglycolytic drug with limited efficacy. Mito-lonidamine is lonidamine conjugated to a triphenylphosphonium moiety via a decyl-linker which is an effective mitochondria-targeting group. Mito-lonidamine was shown to be100-fold more potent than lonidamine. It is a tumor-selective inhibitor of oxidative phosphorylation inhibiting mitochondrial bioenergetics in lung cancer cells and suppressing lung cancer cell viability, growth, progression and metastasis of lung cancer xenografts in mice.

Application Procedures

First dissolved in DMSO (30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.