Minoxidil, K-ATP channel opener (TBI1214)

Description

Product Details

Formal Name: 6-Piperidine-1-ylpyrimidine-2,4-diamine 3-oxide

Molecular Formula: C₉H₁₅N₅O

Formula Weight: 209.25

CAS Number: 38304-91-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

K-ATP channel opener

Functions

Minoxidil is a direct antihypertensive peripheral vasodilator acting via activation of KATP channels leading to relaxation of smooth muscle. Active metabolite is Minoxidil sulfate (IC50 = 0.14 µM). Mainly used as a treatment for alopecia because of its observed hair regrowth ability.

Application Procedures

First dissolved in DMSO (up to 5 mg/ml) or in Ethanol (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 3 months.