Methotrexate, Dihydrofolate reductase inhibitor; Inhibits DNA synthesis (TBI1260)

Description

Product Details

Formal Name: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

Alternate Names: Amethopterin; CL-14377; NSC740

Molecular Formula: C₂₀H₂₂N₈O₅ ∙ xH₂O

Formula Weight: 554.40

CAS Number: 133073-73-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 45 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Dihydrofolate reductase inhibitor; Inhibits DNA synthesis

Functions

A synthetic folic acid analog with immunosuppressant and cancer chemotherapeutic activity. Inhibits thymidylate synthetase and de novo purine synthesis. Displays beneficial effects in rheumatoid arthritis by inhibiting the production of cytokines induced by T-cell activation and stimulation of adenosine release. It is the classic disease-modifying antirheumatic drug (DMARD).

Application Procedures

First dissolved in DMSO (up to 45 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.