MDL-800, SIRT6 allosteric activator (TBI4415)

Description

Product Details

Formal Name: Methyl 2-(N-(5-Bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate

Molecular Formula: C₂₁H₁₆BrCl₂FN₂O₆S₂

Formula Weight: 626.30

CAS Number: 2275619-53-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml with warming)

Storage: -20°C

Stability: ≥ 1 year.

Applications

SIRT6 allosteric activator

Functions

Specific, allosteric activator of SIRT6 (EC50 = 10.3 µM) activity toward H3K9ac and H3K56ac. MDL-800 is ten times less potent against Sirtuins 2, 5, and 7, and is inactive against HDACs 1 through 111. At 20 µM, it induced DNA repair in iPSCs derived from aged mice, promoting genomic integrity and differentiation potential. Inhibits NSCLC cell proliferation (IC50 ~ 30 µM), and suppressed tumor growth in a HCC827 xenograft mouse model.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.