MDL-28170 (Z-Val-Phe-CHO), Calpain inhibitor (TBI3005)

Description

Product Details

Formal Name: N-Benzyloxycarbonylvalylphenylalaninal

Alternate Names: Z-Val-Phe-CHO; Calpain Inhibitor III

Molecular Formula: C₂₂H₂₆N₂O₄

Formula Weight: 382.40

CAS Number: 88191-84-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 75 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Calpain inhibitor

Functions

A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons. It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia. Displays neuroprotective effects in neurotrama rodent models. Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 µM in intact cell assay.

Application Procedures

First dissolved in DMSO (up to 75 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.