Lomerizine, Calcium channel blocker (TBI4336)

Description

Product Details

Formal Name: 1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Alternate Names: KB-2796

Molecular Formula: C₂₇H₃₀F₂N₂O₃·2HCl

Formula Weight: 541.46

CAS Number: 101477-54-7

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (> 45 mg/ml) or in Ethanol (up to 30 mg/mL)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Calcium channel blocker

Functions

Lomerizine is a clinically useful calcium channel blocker (L and T-type). It is used for the treatment of migraine headaches, however its antimigraine effects are believed to be due to its 5HT2A antagonistic effects. Lomerizine also displays anti-glaucoma effects via an increase in ocular circulation and protection of neuronal cells against retinal neurotoxicity with minimal cardiovascular effects. Lomerizine has also shown various other neuroprotective properties.

Application Procedures

First dissolved in DMSO (> 45 mg/ml) or in Ethanol (up to 30 mg/mL), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.