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TribioScience | SKU: TBI4017-10MG

Lomeguatrib, MGMT inhibitor (TBI4017)

Name: Lomeguatrib, MGMT inhibitor (TBI4017)
Brand: TribioScience
SKU: TBI4017-10MG
Price: 90.0 USD
Availability: InStock

$90.00

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Product Description

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TribioScience

Lomeguatrib, MGMT inhibitor (TBI4017)

From $90.00

Description

Product Details

Formal Name: 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine

Alternate Names: O6-(4-Bromothenyl)guanine

Molecular Formula: C₁₀H₈BrN₅O₃S

Formula Weight: 326.20

CAS Number: 192441-08-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml with warming)

Storage: -20°C

Stability: ≥ 1 year.

Applications

MGMT inhibitor

Functions

Lomeguatrib is a potent (IC50 = 9 nM) inhibitor of O6-Methylguanine-DNA Methyltransferase (MGMT), an important DNA repair protein. It is currently being investigated in cancers that have acquired resistant to the chemotherapeutic temozolomide2-5, as well as other chemotherapeutics.