LDN-57444, DUB inhibitor (TBI1303)

Description

Product Details

Formal Name: 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)

Molecular Formula: C₁₇H₁₁Cl₃N₂O₃

Formula Weight: 397.65

CAS Number: 668467-91-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

DUB inhibitor

Functions

Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 week.