KL-001, Cryptochrome (CRY) activator (TBI1411)

Description

Product Details

Formal Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide

Molecular Formula: C₂₁H₂₂N₂O₄S

Formula Weight: 398.46

CAS Number: 309928-48-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml with warming).

Storage: RT

Stability: ≥ 2 years.

Applications

Cryptochrome (CRY) activator

Functions

A novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes. Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure. Induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression in mammalian cells.

Application Procedures

First dissolved in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.