Ketoconazole, Cytochrome P450 inhibitor (TBI1015)

Description

Product Details

Formal Name: (±)-1-[4-(4-{[-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one

Molecular Formula: C₂₆H₂₈Cl₂N₄O₄

Formula Weight: 531.43

CAS Number: 65277-42-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

Cytochrome P450 inhibitor

Functions

Ketoconazole is a broad spectrum antifungal agent which acts via inhibition of a cytochrome P450, CYP51A1 which is a lanosterol 14α-demethylase. Also inhibits CYP3A and CYP1A1. Inhibits adrenal steroidogenesis. Downregulates cholesterol synthesis in drug-tolerant human lung cancer cell lines. Blocks the biosynthesis of leukotrienes (LT) via inhibition of 5-lipoxygenase and dose dependently inhibits LT-mediated bronchoconstriction in guinea pigs.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.