KC7F2, HIF-1a Inhibitor (TBI4714)

Description

Product Details

Formal Name: N,N’-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide

Molecular Formula: C₁₆H₁₆C_l4N₂O₄S₄

Formula Weight: 570.4

CAS Number: 927822-86-4

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

HIF-1a Inhibitor

Functions

Inhibits HIF-1α (IC50 = 20 µM in a HIF-reporter cell line). It suppresses mTORC1 phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K), thereby down-regulating translation of HIF-1α transcripts into protein1. It shows marked dose-response cytotoxicity (IC50 = 15 – 25 µM) in cancer cell lines such as MCF7 and A5491. Decreases viability of epidermal stem cells in a wound healing model. Treatment with 10 μM KC7F2 significantly reduced NKCC1, but not NFAT5, expression in hippocampal neurons in a model of hypoxia-ischemia.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.