KB-R7943 mesylate, TRPC channel blocker (TBI1163)

Description

Product Details

Formal Name: 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioures mesylate

Molecular Formula: C₁₆H₁₇N₃O₃S ∙ CH₃SO₃H

Formula Weight: 427.49

CAS Number: 182004-65-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

TRPC channel blocker

Functions

KB-R7943 is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50’s = 1.2-2.4 µM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts; 0.7µM in cultured rat forebrain). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) – Ki = 5.5 µM. Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 µM) and block NMDA receptors (IC50 = 13.4 µM).

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.