Isohelenin, NFkB inhibitor (TBI5393)

Description

Product Details

Formal Name: (3aR,8aR,9aR)-8a-methyl-3,5-dimethylenedecahydronaphtho[2,3-b]furan-2(3H)-one

Alternate Names: Isoalantolactone

Molecular Formula: C₁₅H₂₀O₂

Formula Weight: 232.30

CAS Number: 470-17-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (50 mg/ml); or Ethanol (30 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

NFkB inhibitor

Functions

A sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 µM) acting via inhibition of IKKß6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression, iNOS expression and RANTES biosynthesis. Displays protective effects in endotoxic shock in rodent models. Induces apoptosis in glioma cells.

Application Procedures

First dissolved in DMSO (50 mg/ml); or Ethanol (30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.