IPA-3, Selective inhibitor of PAK1 (TBI4765)

Description

Product Details

Formal Name: 1,1′-Dithiodi-2-naphthol

Molecular Formula: C₂₀H₁₄O₂S₂

Formula Weight: 350.45

CAS Number: 42521-82-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Selective inhibitor of PAK1

Functions

IPA-3 is a selective allosteric inhibitor of Group 1 p21-activated kinase (PAK1 IC50 = 2.5 µM) via covalent binding to the PAK1 regulatory domain preventing binding to the upstream activator Cdc42. IPA-3 has been shown to induce cell death in human leukemic cell lines, significantly inhibit TGFβ1-induced prostate cell epithelial to mesenchymal transition and inhibits the growth of liver cancer cells.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.