Indirubin, AhR ligand (TBI1383)

Description

Product Details

Formal Name: 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one

Alternate Names: Indigo red; Couroupitine B; Indigopurpurin

Molecular Formula: C₁₆H₁₀N₂O₂

Formula Weight: 262.30

CAS Number: 479-41-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml).

Storage: RT

Stability: ≥ 1 year.

Applications

AhR ligand

Functions

Natural product that acts as an inducer of human AhR-dependent gene expression with 10-fold greater potency over the endogenous agonist TCDD. Indirubin also inhibits CDKs (IC50 = 50–100 nM) and GSK-3β (IC50 = 5-50 nM). Ameliorates the effects of a high-fat diet on mice. Breaks the inflammatory cycle in in vitro and in vivo models of psoriasis. Inhibits angiogenesis and causes autophagy and apoptosis in cancer cells.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer.