Importazole, Importin-b-mediated nuclear import blocker (TBI1412)

Description

Product Details

Formal Name: N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine

Alternate Names: IPZ

Molecular Formula: C₂₀H₂₂N₄

Formula Weight: 318.43

CAS Number: 662163-81-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml).

Storage: RT

Stability: ≥ 1 year.

Applications

Importin-b-mediated nuclear import blocker

Functions

Specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export. When added to cells during mitosis it impairs the release of an importin-β cargo probe and causes defects in spindle assembly. Inhibition of importin-β function is most likely mediated by blocking its interaction with RanGTP. It is an important new tool to probe the function of the importin-β/RanGTP pathway. Cell permeable

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.