Icilin, TRPM8 channel activator (TBI4380)

Description

Product Details

Formal Name: 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one

Alternate Names: AG 3-5

Molecular Formula: C₁₆H₁₃N₃O₄

Formula Weight: 311.29

CAS Number: 36945-98-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

TRPM8 channel activator

Functions

Icilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 µM for CRM1, rat orthologue of TRPM8). Agonist at TRPM8 (EC50 = 0.2 µM) and ANKTM1(TRPA1). Agonist effects require Ca2+ and are pH dependent. Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.