HTS01037, FABP inhibitor (TBI1453)

Description

Product Details

Formal Name: 4-[(3-Carboxy-1-oxo-2-propen-1-yl)amino]-[2,2’-bithiophene]-5-carboxylic acid, 5-methyl ester

Molecular Formula: C₁₄H₁₁NO₅S₂

Formula Weight: 337.37

CAS Number: 682741-29-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

FABP inhibitor

Functions

Inhibits fatty acid binding proteins. Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages. Acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophages. Inhibits FABP-dependent and fatty acid-stimulated leukotriene C4 biosynthesis. Reduces intracellular free fatty acid levels, lowering macrophage inflammation and ER stress3. Reduces LPS-stimulated IL-1β secretion in a mouse model. Inhibits VLDL-induced foam cell formation.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.