Harmine HCl, MAO-A and DYRK inhibitor (TBI4520)

Description

Product Details

Formal Name: 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride

Molecular Formula: C₁₃H₁₂N₂O·HCl

Formula Weight: 248.71

CAS Number: 343-27-1

Purity: >98%

Formulation: powder

Solubility: Soluble in Water (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

MAO-A and DYRK inhibitor

Functions

Selective competitive and reversible inhibitor of MAO-A (IC50 = 8 µM). Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC50’s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 µM; DYRK4 = 80 µM). Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells(GSLC’s) possibly via inhibition of Akt phosphorylation. Harmine has also been shown to possess antimicrobial, antifungal, antiplasmodial, antitumor, antioxidant, antimutagenic and antigenotoxic properties. Inhibits osteoclast differentiation and bone resorption via downregulation of c-Fos and NFATc1 induced by RANKL.

Application Procedures

First dissolved in Water (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in distilled water may be stored at -20° for up to 3 months.