H89 · 2HCl, PKA inhibitor (TBI2144)

Description

Product Details

Formal Name: N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride

Molecular Formula: C₂₀H₂₀BrN₃O₂S·2HCl

Formula Weight: 519.28

CAS Number: 127243-85-0

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Water (up to 10 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

• PKA inhibitor

Functions

H-89 (127243-85-0) is a commonly used inhibitor of protein kinase A (PKA IC₅₀ = 140 nM). Inhibits a variety of other kinases including S6K1 (IC₅₀ = 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 µM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 µM).

Application Procedures

Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.