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TribioScience  |  SKU: TBI4132-10MG

H-151, STING antagonist (TBI4132)

$117.00
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TribioScience

H-151, STING antagonist (TBI4132)

From $117.00

Description

Product Details

Formal Name: N-(4-Ethylphenyl)-N’-1H-indol-3-yl urea

Molecular Formula: C17H17N3O

Formula Weight: 279.34

CAS Number: 941987-60-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

STING antagonist

Functions

H-151 is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Option

  • 10 MG
  • 50 MG
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