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TribioScience | SKU: TBI1031-5MG

GW-5074, c-Raf1 inhibitor (TBI1031)

Name: GW-5074, c-Raf1 inhibitor (TBI1031)
Brand: TribioScience
SKU: TBI1031-5MG
Price: 108.0 USD
Availability: InStock

$108.00

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TribioScience

GW-5074, c-Raf1 inhibitor (TBI1031)

From $108.00

Description

Product Details

Formal Name: 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one

Molecular Formula: C₁₅H₈Br₂INO₂

Formula Weight: 520.95

CAS Number: 220904-83-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

c-Raf1 inhibitor

Functions

Potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective effects In vivo via a mechanism that is independent of MEK, ERK, and Akt signaling. Cell permeable.