Guggulsterone (Z-), FXR antagonist (TBI3816)

Description

Product Details

Formal Name: (Z)-Pregna-4,17(20)-diene-3,16-dione

Molecular Formula: C₂₁H₂₈O₂

Formula Weight: 312.45

CAS Number: 39025-23-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 6 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

FXR antagonist

Functions

A natural steroid from Commiphora mukul extract (guggulipid) which lowers cholesterol and acts as an FXR antagonist. Attenuates astrocyte-mediated neuroinflam-mation. Induces differentiation of pluripotent stem cells to dopaminergic neurons. Produces antidepressant-like effects via activation of the BDNF signaling pathway in mouse models.

Application Procedures

First dissolved in DMSO (up to 6 mg/ml with warming) or in Ethanol (up to 3 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.