GSK-690693 HCl, Akt inhibitor (TBI1310)

Description

Product Details

Formal Name: (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridine-4-yl)-2-methylbut-3-yn-2-ol · HCl

Molecular Formula: C₂₁H₂₇N₇O₃ · HCl

Formula Weight: 461.96

CAS Number: 937174-76-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 30 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Akt inhibitor

Functions

A novel ATP-competitive pan-specific Akt kinase inhibitor. (IC50’s=2, 13, 9 nM for Akt1, 2 and 3 respectively) Antitumor activity. Active in vivo. Induces hyperglycemia. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml) or in Ethanol (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.