GF-109203X, PKC inhibitor (TBI1026)

Description

Product Details

Formal Name: 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide

Alternate Names: Gö 6850; Bisindolylmaleimide I

Molecular Formula: C₂₅H₂₄N₄O₂

Formula Weight: 412.49

CAS Number: 133052-90-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

PKC inhibitor

Functions

Potent and selective protein kinase C inhibitor (IC50 = 10 nM; cAMP-dependent protein kinase IC50 = 2 µM and phosphorylase kinase IC50 = 0.7 µM). Inactive against the tyrosine kinases EGFR, PGDFR and Insulin receptor. Potent inhibitor of GSK-3β in cell lysates (IC50 = 360nM) and GSK-3β immunoprecipitates (IC50 = 170nM) derived from rat epididymal adipocytes. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 6 months.