Formoterol hemifumarate, β2-adrenergic agonist, potent and selective (TBI5092)

Description

Product Details

Formal Name: (R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide

Alternate Names: BD 40A

Molecular Formula: C₁₉H₂₄N₂O₄ • ½C₄H₄O₄

Formula Weight: 402.50

CAS Number: 43229-80-7

Purity: >99%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml)

Storage: RT

Stability: ≥ 2 years.

Applications

β2-adrenergic agonist, potent and selective

Functions

Potent, long-acting agonist specific to β2 (Ki = 7.6 nM), but not β1 (Ki > 2.6 µM), adrenergic receptors in trachea (pD2 = 9.3) over atrium (pD2 = 7.0). Reduces adhesion and superoxide anion production in cultured activated eosinophils. Reverses cachexia in rats and mice via inhibition of the ATP-ubiquitin-dependent proteolytic system. Rescues LPS-induced motor function deficits and nigrostriatal dopamine loss in a rat model of Parkinson’s. Clinically useful for respiratory diseases.

Application Procedures

First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.