ERGi-USU, Highly selective ERG inhibitor (TBI4290)

Description

Product Details

Formal Name: 1-(2-Thiazolylazo)-2-naphthol

Alternate Names: NSC139021

Molecular Formula: C₁₃H₉N₃OS

Formula Weight: 255.30

CAS Number: 1147-56-4

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 10 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Highly selective ERG inhibitor

Functions

ERGi-USU selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.

Application Procedures

First dissolved in DMSO (up to at least 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.