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TribioScience  |  SKU: TBI4423-5MG

Epalrestat, Aldose reductase inhibitor (TBI4423)

$90.00
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TribioScience

Epalrestat, Aldose reductase inhibitor (TBI4423)

From $90.00

Description

Product Details

Formal Name: 2-[(5Z)-5-[(E)-3-phenyl-2-methylprop-2-enylidene]- 4-oxo-2-thioxo-3-thiazolidinyl]acetic acid

Alternate Names: ONO-2235

Molecular Formula: C15H13NO3S2

Formula Weight: 319.40

CAS Number: 82159-09-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 5 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Aldose reductase inhibitor

Functions

Epalrestat is an aldose reductase inhibitor (IC50 = 10 nM (rat lens) and 25 nM (human placenta). It reduces sorbitol accumulation in the sciatic nerve, erythrocytes and ocular tissue. May be used to prevent or slow the progression of diabetic neuropathy.

Application Procedures

First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.

Option

  • 5 MG
  • 25 MG
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