Embelin, XIAP inhibitor; Apoptosis inducer (TBI2959)

Description

Product Details

Formal Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione

Molecular Formula: C₁₇H₂₆O₄

Formula Weight: 294.39

CAS Number: 550-24-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

XIAP inhibitor; Apoptosis inducer

Functions

Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 μM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells3. Possesses anti-inflammatory and analgesic activity in vivo4. Cell-permeable.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 2 months.