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TribioScience  |  SKU: TBI1561-5MG

DY-131, Estrogen receptor ERRb and ERRg agonist (TBI1561)

$90.00
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TribioScience

DY-131, Estrogen receptor ERRb and ERRg agonist (TBI1561)

From $90.00

Description

Product Details

Formal Name: N-(4-(Diethylaminobenzylidenyl)-N’-(4-hydroxybenzoyl)-hydrazine

Alternate Names: GSK-9089

Molecular Formula: C18H21N3O2

Formula Weight: 311.38

CAS Number: 95167-41-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Estrogen receptor ERRb and ERRg agonist

Functions

Selective agonist at estrogen-related receptors ERRβ and ERRɣ with minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. Displays antiproliferative activity in prostate cancer cells. Promotes hormone production and cell fusion in cytotrophoblasts. In breast cancer cells DY131 arrests cells in G2/M and causes mitotic spindle defects. Inhibits osteoclastogenesis and protects against inflammatory bone loss induced by LPS in vivo.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Option

  • 5 MG
  • 25 MG
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