DSPC/CHOL/mPEG-DSPE (50:45:5 mol/mol) Liposomes with Ammonium Sulfate Gradient (100nm)

Description

DSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Liposomes with Ammonium Sulfate Gradient (100nm)

This product is prepared to the finest quality and shipped to you ready for drug loading. DSPC/CHOL/mPEG-DSPE liposomes with ammonium gradient is the formulator’s choice for loading of weakly basic compounds, because it offers significantly improved drug retention and ease of use in terms of process parameters such as loading temperature (60-70 deg C)

This liposome can be used as the placebo control for the drug-loaded formulation or use the much cheaper plain DSPC liposomes as placebo-control (F10203)

Specifications

Lipid composition: DSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol)

Mean particle size: 100 nm (95 – 120 nm)

Lipid concentration: 60mM (60 – 65 mM)

Hydration buffer (loading battery): 250 mM ammonium sulfate

External solution: 10% sucrose, 20mM sodium PO4, pH 6.5 ± 0.2

Shelf-life: 6 months

Storage: 2-8 °C, do not freeze

DSPC: 18:0 PC,1,2-distearoyl-sn-glycero-3-phosphocholine

CHOL: cholesterol

mPEG2000-DSPE: 18:0 PEG2000 PE:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)