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TribioScience  |  SKU: TBI2909-5MG

DPN, Estrogen ER b agonist (TBI2909)

$90.00
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TribioScience

DPN, Estrogen ER b agonist (TBI2909)

From $90.00

Description

Product Details

Formal Name: 2,3-bis(4-Hydroxyphenyl)-propionitrile

Alternate Names: Diarylpropionitrile

Molecular Formula: C15H13NO2

Formula Weight: 239.27

CAS Number: 1428-67-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Estrogen ER b agonist

Functions

Potent estrogen ERβ receptor agonist. Displays a 70-fold selectivity over ERα, EC50 = 0.85 and 66 nM, respectively. Regulates expression of GluR1, 2 and 3 in rat hippocampus. Ameliorates portal hypertension in a carbon tetrachloride-induced liver cirrhosis rat model. Stimulates proliferation of androgen-independent prostate cancer cell line PC-3 via a novel pathway involving ERβ-mediated activation of β-catenin. A useful tool for elucidating the biological function of ERβ.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Option

  • 5 MG
  • 25 MG
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