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TribioScience  |  SKU: TBI2371-50MG

DMOG, Prolyl hydroxylase inhibitor (TBI2371)

$108.00
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TribioScience

DMOG, Prolyl hydroxylase inhibitor (TBI2371)

From $108.00

Description

Product Details

Formal Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester

Alternate Names: Dimethyloxalylglycine

Molecular Formula: C6H9NO5

Formula Weight: 175.14

CAS Number: 89464-63-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Storage: -20°C / protect from light

Stability: ≥ 2 years.

Applications

Prolyl hydroxylase inhibitor

Functions

Inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α and inhibiting JMJD2A (IC50 = 2.5 μM). Displays neuroprotective effects. Inhibits neuronal cell death caused by neurotrophin deprivation. Prevents activation of the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions are not stable. Solutions must be made fresh and used within 1 working day.

Option

  • 50 MG
  • 100 MG
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