Deferasirox, Iron Chelator (TBI4949)

Description

Product Details

Formal Name: 4-[3,5-bis(2-Hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid

Alternate Names: ICL670

Molecular Formula: C₂₁H₁₅N₃O₄

Formula Weight: 373.36

CAS Number: 201530-41-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Iron Chelator

Functions

Clinically useful iron chelator used in long term care of ß-thalassemia and other heavily transfused hematological patients. It has been shown to potent inhibitor of JumonjiC Domain-Containing Histone Demethylases (IC50’s = KDM4A(JMJD2A) 4.76 µM, KDM5A(JARID1A) 5.00 µM, KDM6B(JMJD3) 3.95 µM). Deferasirox has also been investigated as a potential anticancer agent.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.