Dantrolene Na, SR calcium release inhibitor (TBI2208)

Description

Product Details

Formal Name: 1-[(5-(p-Nitrophenyl)furfurylidene)amino]hydantoin sodium salt

Molecular Formula: C₁₄H₉N₄O₅ Na

Formula Weight: 336.23

CAS Number: 14663-23-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 3 mg/ml) or in a 1:1 mixture of DMF and Ethanol (up to 20 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

SR calcium release inhibitor

Functions

Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor channels with selectivity for RYR1 and RYR3 over RYR2. Protects against quisqualate and NMDA-induced cytotoxicity in cultured cerebral cortical neurons. Displays neuroprotective effects. Prevents cell death in neural progenitor cells derived from Wolfram syndrome iPS cells.

Application Procedures

First dissolved in DMSO (up to 3 mg/ml) or in a 1:1 mixture of DMF and Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, DMF, or Ethanol may be stored at -20°C for up to 1 month.