Concanamycin A, V-ATPase inhibitor

Description

Product Details

Alternate Names: Folimycin

Molecular Formula: C₄₆H₇₅NO₁₄

Formula Weight: 866.10

CAS Number: 80890-47-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

V-ATPase inhibitor

Functions

A potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines. Inhibits cell surface expression of virus envelope glycoproteins. Dramatically increases the rate of extracellular vesicle release from a variety of cell types. Inhibits autophagy by blocking lysosomal acidification.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.