Compound 147 (AA147), ATF6 activator; ER proteostasis (TBI3973)

Description

Product Details

Formal Name: N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide

Molecular Formula: C₁₆H₁₇NO₂

Formula Weight: 255.3

CAS Number: 393121-74-9

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

ATF6 activator; ER proteostasis

Functions

Compound 147 is a preferential activator of the ER stress sensing protein ATF6. It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. Compound 147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases. Compound 147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion. It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner. Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. Compound 147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.