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TribioScience  |  SKU: TBI4631-10MG

Clodronate 2Na, Bis-phosphonate; Osteoclast apoptosis agent (TBI4631)

$54.00
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TribioScience

Clodronate 2Na, Bis-phosphonate; Osteoclast apoptosis agent (TBI4631)

From $54.00

Description

Product Details

Formal Name: Dichloromethylenediphosphonic acid disodium tetrahydrate

Molecular Formula: CH2Cl2O6P2·2Na·4H2O

Formula Weight: 360.92

CAS Number: 88416-50-6

Purity: >98%

Formulation: Powder

Solubility: Soluble in water (up to at least 10 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Bis-phosphonate; Osteoclast apoptosis agent

Functions

Clodronate is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer. It strongly binds to hydroxyapatite and directly reduces osteoclast activity. Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.

Application Procedures

First dissolved in water (up to at least 10 mg/ml), then diluted to aqueous buffer. Solutions in distilled water may be stored at -20°C for up to 3 months.

Option

  • 10 MG
  • 50 MG
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