Cilastatin Na, Dipeptidase inhibitor; DPEP1 inhibitor (TBI2233)

Description

Product Details

Formal Name: (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]-carbonyl]amino]-2-heptenoic acid, sodium salt

Alternate Names: MK 0791

Molecular Formula: C₁₆H₂₅N₂O₅S Na

Formula Weight: 380.43

CAS Number: 81129-83-1

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 3 mg/ml) or in Water (up to 35 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Dipeptidase inhibitor; DPEP1 inhibitor

Functions

Dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4. Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus is used as an antibacterial adjunct to extend the half-life of β-lactam antibiotics. Cilastatin also inhibits bacterial metallo-β-lactamase and thereby may block resistance to the carbapenem family of antibiotics in certain bacteria. Suppresses invasion and metastasis of DPEP1-expressing tumor cells.

Application Procedures

First dissolved in DMSO (up to 3 mg/ml) or in Water (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.