CHS-828 (GMX-1778), NAMPT inhibitor (TBI1390)

Description

Product Details

Formal Name: N-[6-(4-chlorophenoxy)hexyl]-N’-cyano-N”-4-pyridinyl-guanidine

Alternate Names: GMX-1778

Molecular Formula: C₁₉H₂₂ClN₅O

Formula Weight: 371.86

CAS Number: 200484-11-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

NAMPT inhibitor

Functions

A potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the biosynthesis of NAD, which may be used to deplete cells of NAD. Displays potent cytotoxic effects in tumor cells. Displays antitumor activity in vivo. Increases ROS levels in cancer cells but not in normal cells.

Application Procedures

First dissolved in DMSO up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.