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TribioScience | SKU: TBI5635-100UG

Calphostin C, Protein Kinase C inhibitor (TBI5635)

Name: Calphostin C, Protein Kinase C inhibitor (TBI5635)
Brand: TribioScience
SKU: TBI5635-100UG
Price: 263.0 USD
Availability: InStock

$263.00

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TribioScience

Calphostin C, Protein Kinase C inhibitor (TBI5635)

From $263.00

Description

Product Details

Formal Name: Fermentation product from Cladisporium cladosporioides

Alternate Names: UCN-1028C; PKF115-584

Molecular Formula: C₄₄H₃₈O₁₄

Formula Weight: 790.80

CAS Number: 121263-19-2

Purity: >95%

Formulation: powder

Solubility: Soluble in DMSO (10 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Protein Kinase C inhibitor

Functions

A potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM). Inhibition of PKC is light dependent and is competitive with the diacylglycerol / phorbol ester binding site. Calphostin C competes with the diacylglycerol / phorbol ester binding site in other proteins such as Munc13-1. Reverses oxycodone-induced tolerance to respiratory depression.