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TribioScience | SKU: TBI4131-10MG

C-178, STING antagonist (TBI4131)

Name: C-178, STING antagonist (TBI4131)
Brand: TribioScience
SKU: TBI4131-10MG
Price: 72.0 USD
Availability: InStock

$72.00

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TribioScience

C-178, STING antagonist (TBI4131)

From $72.00

Description

Product Details

Formal Name: N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide

Molecular Formula: C11H7IN2O4

Formula Weight: 358.09

CAS Number: 314054-00-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

STING antagonist

Functions

C-176 is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. Treatment of Trex-/- mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.