BT2, BCKDC kinase inhibitor (TBI4717)

Description

Product Details

Formal Name: 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid

Molecular Formula: C₉H₄Cl₂O₂S

Formula Weight: 247.10

CAS Number: 34576-94-8

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 20 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

BCKDC kinase inhibitor

Functions

BT2 is an inhibitor of the mitochondrial branched-chain α-ketoacid dehydrogenase complex kinase (BCKDC) – IC50 = 3.19 µM. Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 has also been shown to be a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein.

Application Procedures

First dissolved in DMSO (up to at least 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.