BPTES, Glutaminase GLS1 inhibitor (TBI5414)

Description

Product Details

Formal Name: N,N’-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide

Molecular Formula: C₂₄H₂₄N₆O₂S₃

Formula Weight: 524.70

CAS Number: 314045-39-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (10 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Glutaminase GLS1 inhibitor

Functions

A potent and selective allosteric inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 µM. Selective for GLS1 over GLS2, ɣ-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia. Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment. BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression. Clears senescent cells and improves various age-related disorders in a geriatric mouse model.

Application Procedures

First dissolved in DMSO (10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.