BMS-303141, ATP citrate lyase (ACL) inhibitor (TBI1414)

Description

Product Details

Formal Name: 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1’-biphenyl]-3-yl)-benzenesulfonamide

Molecular Formula: C₁₉H₁₅Cl₂NO₄S

Formula Weight: 424.30

CAS Number: 943962-47-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

ATP citrate lyase (ACL) inhibitor

Functions

Potent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 μM. Inhibits lipid biosynthesis, IC50=8 μM in HepG2 cells. Reduces weight gain, lowers plasma cholesterol, triglycerides and glucose in high-fat-fed mice. A novel tool compound for exploring the potential of ACL inhibition as a target for metabolic disorders such as obesity and dyslipidemia. Impairs proliferation or induces death in androgen-depleted castration resistant prostate cancer cells. Reduces cell cycle progression in iBN cells.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.