BML-277, CHK2 inhibitor (TBI1024)

Description

Product Details

Formal Name: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide

Molecular Formula: C₂₀H₁₄ClN₃O₂

Formula Weight: 363.81

CAS Number: 516480-79-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

CHK2 inhibitor

Functions

Potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 µM, demonstrating the selectivity. Also displays radioprotective activity, preventing apoptosis in human T-cells that were subjected to ionizing radiation (EC50 = 3.0 – 7.6 µM).

Application Procedures

First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.