BIIB021, HSP90 Inhibitor (TBI4641)

Description

Product Details

Formal Name: 6-Chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-amine

Alternate Names: CNF2024

Molecular Formula: C₁₄H₁₅ClN₆O

Formula Weight: 318.80

CAS Number: 848695-25-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

HSP90 Inhibitor

Functions

BIIB021 is a potent HSP90 inhibitor (IC50 = 30 nM HER-2 degradation). It inhibited the proliferation of MCF7 and BT474 breast cancer cell lines (IC50 = 100 nM for each). BIIB021 has shown efficacy as a therapeutic in multiple cancer models.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.